Long-term outcomes of pouch surveillance and risk of neoplasia in familial adenomatous polyposis.

ABSTRACT:

Background

 Long-term pouch surveillance outcomes for familial adenomatous polyposis (FAP) are unknown. We aimed to quantify surveillance outcomes and to determine which of selected possible predictive factors are associated with pouch dysplasia.

Methods

 Retrospective analysis of collected data on 249 patients was performed, analyzing potential risk factors for the development of adenomas or advanced lesions ( ≥ 10 mm/high grade dysplasia (HGD)/cancer) in the pouch body and cuff using Cox proportional hazards models. Kaplan-Meier analyses included landmark time-point analyses at 10 years after surgery to predict the future risk of advanced lesions.

Results

 Of 249 patients, 76 % developed at least one pouch body adenoma, with 16 % developing an advanced pouch body le

SUBMITTER: Patel RV 

PROVIDER: S-EPMC10465241 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature