Hypoxia Differentially Affects Chondrogenic Differentiation of Progenitor Cells from Different Origins.

ABSTRACT:

Background and objectives

Ear cartilage malformations are commonly encountered problems in reconstructive surgery, since cartilage has low self-regenerating capacity. Malformations that impose psychological and social burden on one's life are currently treated using ear prosthesis, synthetic implants or autologous flaps from rib cartilage. These approaches are challenging because not only they request high surgical expertise, but also they lack flexibility and induce severe donor-site morbidity. Through the last decade, tissue engineering gained attention where it aims at regenerating human tissues or organs in order to restore normal functions. This technique consists of three main elements, cells, growth factors, and above all, a scaffold that supports cells and guides their beha

SUBMITTER: Hammad M 

PROVIDER: S-EPMC10465331 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature