Rx and its downstream factor, Musashi1, is required for establishment of the apical organ in sea urchin larvae.

ABSTRACT: Acetylcholine, a vital neurotransmitter, plays a multifarious role in the brain and peripheral nervous system of various organisms. Previous research has demonstrated the proximity of cholinergic neurons to serotonergic neurons in the apical organ of sea urchin embryos. While several transcription factors have been identified as playing a role in the development of serotonergic neurons in this region of a sea urchin, Hemicentrotus pulcherrimus, comparatively little is known about the specific transcription factors and their spatiotemporal expression patterns that regulate the development of cholinergic neurons. In this study, we establish the requirement of the transcription factor Rx for the development of cholinergic neurons in the apical organ of the species. Furthermore, we inve

SUBMITTER: Yaguchi J 

PROVIDER: S-EPMC10465340 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature