A novel m6A/m5C/m1A score signature to evaluate prognosis and its immunotherapy value in colon cancer patients.

ABSTRACT:

Background

Colon cancer features strong heterogeneity and invasiveness, with high incidence and mortality rates. Recently, RNA modifications involving m6A, m5C, and m1A play a vital part in tumorigenesis and immune cell infiltration. However, integrated analysis among various RNA modifications in colon cancer has not been performed.

Methods

RNA-seq profiling, clinical data and mutation data were obtained from The Cancer Genome Atlas and Gene Expression Omnibus. We first explored the mutation status and expression levels of m6A/m5C/m1A regulators in colon cancer. Then, different m6A/m5C/m1A clusters and gene clusters were identified by consensus clustering analysis. We further constructed and validated a scoring system, which could be utilized to accurately assess the risk of

SUBMITTER: Liu J 

PROVIDER: S-EPMC10465387 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature