Integrated analysis of the roles of oxidative stress related genes and prognostic value in clear cell renal cell carcinoma.

ABSTRACT:

Background

Patients with clear cell renal cell carcinoma (ccRCC), which is the most commonly diagnosed subtype of renal cell carcinoma, are at risk of tumor metastasis and recrudescence. Previous research has shown that oxidative stress can induce tumorigenesis in many cancers and can be a target of cancer treatment. Despite these findings, little progress has been made understanding in the association of oxidative stress-related genes (OSRGs) with ccRCC.

Methods

In vitro experiments were conducted with MTT survival assays, qRT‒PCR, apoptosis assays, cell cycle assays, ROS assays, and IHC staining.

Results

In our study, 12 differentially expressed oxidative stress-related genes (DEOSGs) and related transcription factors (TFs) that are relevant to overall survival (OS)

SUBMITTER: Wang D 

PROVIDER: S-EPMC10465389 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature