OSR1 downregulation indicates an unfavorable prognosis and activates the NF-κB pathway in ovarian cancer.

ABSTRACT:

Background

Odd-skipped related 1 (OSR1) has been reported as a tumor suppressor gene in various malignant tumors. The mechanism through which OSR1 regulates ovarian cancer (OC) progression remains unclear.

Materials and methods

Immunohistochemistry was utilized to evaluate OSR1 expression in patients with ovarian cancer. We investigated the association between clinicopathological parameters and OSR1 expression in OC patients and the influence of OSR1 expression on patient survival and prognosis. OC cells with OSR1 overexpression or knockdown were established and validated using Western blot and Quantitative reverse-transcription polymerase chain reaction (qRT-PCR). The influence of OSR1 on the NF-κB pathway was examined by analyzing the p-IκBα, IκBα, p65, and p-p65 protein e

SUBMITTER: Yu Z 

PROVIDER: S-EPMC10465422 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature