Caveolin-1 promotes glioma progression and maintains its mitochondrial inhibition resistance.

ABSTRACT:

Background

Glioma is a lethal brain cancer and lacking effective therapies. Challenges include no effective therapeutic target, intra- and intertumoral heterogeneity, inadequate effective drugs, and an immunosuppressive microenvironment, etc. Deciphering the pathogenesis of gliomas and finding out the working mechanisms are urgent and necessary for glioma treatment. Identification of prognostic biomarkers and targeting the biomarker genes will be a promising therapy.

Methods

From our RNA-sequencing data of the oxidative phosphorylation (OXPHOS)-inhibition sensitive and OXPHOS-resistant cell lines, we found that the scaffolding protein caveolin 1 (CAV1) is highly expressed in the resistant group but not in the sensitive group. By comprehensive analysis of our RNA sequencing d

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10465474 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature