γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection.

ABSTRACT: African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in a murine model of infection using spatial and single cell transcriptomics. We detect expansion of dermal IL-17A-producing Vγ6⁺ cells during infection, which occurs in the subcutaneous adipose tissue. In silico cell-cell communication analysis suggests that subcutaneous interstitial preadipocytes trigger T cell activation via Cd40 and Tnfsf18 signalling, amongst others. In vivo, we observe that female mice deficient for IL-17A-producing Vγ6⁺ cells show extensive inflammation and limit subcutaneous adipose tissue wasting, independently of parasite burden. Based on

SUBMITTER: Quintana JF 

PROVIDER: S-EPMC10465518 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature