Clarifying the composition of the ATP consumption factors required for maintaining ion homeostasis in mouse rod photoreceptors.

ABSTRACT: To date, no effective treatment has been established for photoreceptor loss due to energy imbalances, but numerous therapeutic approaches have reported some success in slowing photoreceptor degeneration by downregulating energy demand. However, the detailed mechanisms remain unclear. This study aimed to clarify the composition of ATP consumption factors in photoreceptors in darkness and in light. We introduced mathematical formulas for ionic current activities combined with a phototransduction model to form a new mathematical model for estimating the energy expenditure of each ionic current. The proposed model included various ionic currents identified in mouse rods using a gene expression database incorporating an available electrophysiological recording of each specific gene. ATP was mai

SUBMITTER: Muangkram Y 

PROVIDER: S-EPMC10465610 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature