MicroRNA expression associated with low-grade cervical intraepithelial neoplasia outcomes.

ABSTRACT:

Purpose

Only a fraction of low-grade cervical intraepithelial neoplasia (CIN) progresses to high-grade CIN; however, the biological processes that differentiate progressive CIN from CIN that resolves naturally are poorly understood. MicroRNAs (miRNAs) are important epigenetic regulators of gene expression and thus, miRNA expression profiling can reveal the dysregulated biology underlying disease processes. The purpose of this case-control study was to reveal miRNA expression patterns and predict the underlying biological pathways that are associated with clinical outcomes of low-grade CIN.

Methods

Women with low-grade CIN diagnosis and definitive clinical outcomes (n = 51) were identified retrospectively using electronic clinical records. Comprehensive miRNA expression profi

SUBMITTER: Winters AN 

PROVIDER: S-EPMC10465678 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature