A risk prognostic model for patients with esophageal squamous cell carcinoma basing on cuproptosis and ferroptosis.

ABSTRACT:

Background

Cuproptosis, a form of copper-dependent programmed cell death recently presented by Tsvetkov et al., have been identified as a potential therapeutic target for refractory cancers and ferroptosis, a well-known form describing iron-dependent cell death. However, whether the crossing of cuproptosis-related genes and ferroptosis-related genes can introduce some new idea, thus being used as a novel clinical and therapeutic predictor in esophageal squamous cell carcinoma (ESCC) remains unknown.

Methods

We collected ESCC patient data from the Gene Expression Omnibus and the Cancer Genome Atlas databases and used Gene Set Variation Analysis to score each sample based on cuproptosis and ferroptosis. We then performed weighted gene co-expression network analysis to identify

SUBMITTER: Li J 

PROVIDER: S-EPMC10465684 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature