Environmental conditions define the energetics of bacterial dormancy and its antibiotic susceptibility.

ABSTRACT: Bacterial cells that stop growing but maintain viability and the capability to regrow are termed dormant and have been shown to transiently tolerate high concentrations of antimicrobials. Links between tolerance and cellular energetics as a possible explanation for the tolerance, have been investigated and have produced mixed and seemingly contradictory results. Because dormancy merely indicates growth arrest, which can be induced by various stimuli, we hypothesize that dormant cells may exist in a range of energetic states that depend on the environment. To energetically characterize different dormancies, we first induce them in a way that results in dormant populations and subsequently measure both of their main energy sources, the proton motive force magnitude and the concentration of A

SUBMITTER: Mancini L 

PROVIDER: S-EPMC10465703 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature