Inhibitory effect of berberine on morphine tolerance and hyperalgesia in mice.

ABSTRACT:

Objective

To evaluate the effect of berberine on morphine analgesia, tolerance, and hyperalgesia.

Methods

Morphine-induced acute tolerance model: mice received intraperitoneal berberine at doses of 2.5, 5.0, and 10 mg/kg; 30 min later, subcutaneous morphine 10 mg/kg was injected every hour for nine continuous h. Morphine 10 mg/kg alone was administered at 24 and 48 h. Morphine-induced chronic tolerance model: mice received intraperitoneal berberine 2.5, 5.0, and 10 mg/kg; 30 min later, 10 mg/kg morphine was injected subcutaneously for eight consecutive days. On the ninth day, morphine 10 mg/kg was given alone. Morphine-induced established tolerance model: mice were injected subcutaneously with morphine 10 mg/kg once a day for eight consecutive days. Berberine 2.5 mg/kg was a

SUBMITTER: Shuai H 

PROVIDER: S-EPMC10465842 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature