Advanced subunit vaccine delivery technologies: From vaccine cascade obstacles to design strategies.

ABSTRACT: Designing and manufacturing safe and effective vaccines is a crucial challenge for human health worldwide. Research on adjuvant-based subunit vaccines is increasingly being explored to meet clinical needs. Nevertheless, the adaptive immune responses of subunit vaccines are still unfavorable, which may partially be attributed to the immune cascade obstacles and unsatisfactory vaccine design. An extended understanding of the crosstalk between vaccine delivery strategies and immunological mechanisms could provide scientific insight to optimize antigen delivery and improve vaccination efficacy. In this review, we summarized the advanced subunit vaccine delivery technologies from the perspective of vaccine cascade obstacles after administration. The engineered subunit vaccines with lymph node a

SUBMITTER: Hou Y 

PROVIDER: S-EPMC10465871 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature