Initial dosage optimisation of cyclosporine in Chinese paediatric patients undergoing allogeneic haematopoietic stem cell transplantation based on population pharmacokinetics: a retrospective study.

ABSTRACT:

Objective

Improved understanding of cyclosporine A (CsA) pharmacokinetics in children undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT) is crucial for effective prevention of acute graft-versus-host disease and medication safety. The aim of this study was to establish a population pharmacokinetic (Pop-PK) model that could be used for individualised therapy to paediatric patients undergoing allo-HSCT in China.

Design, setting and participants

A retrospective analysis of 251 paediatric HSCT patients who received CsA intravenously in the early post transplantation period at Women and Children's Medical Center in Guangzhou was conducted.

Analysis measures

The model building dataset from 176 children was used to develop and analyse the CsA Pop-Pk m

SUBMITTER: Feng H 

PROVIDER: S-EPMC10465907 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature