Safety and efficacy of Vitamin D₃ supplementation with Imatinib in Chronic Phase- Chronic Myeloid Leukaemia: an Exploratory Randomized Controlled Trial.

ABSTRACT:

Objectives

The study aimed to compare early molecular response (EMR) rates at 3 months of imatinib therapy with and without vitamin D₃ supplementation in patients newly diagnosed with chronic-phase chronic myeloid leukaemia (CML-CP). The secondary objective was to assess the effects of vitamin D₃ on complete haematological response (CHR) and its safety.

Design

Double-blind, placebo-controlled, exploratory randomised trial.

Setting

Tertiary care hospital in northern India.

Participants

Treatment-naive patients with chronic phase chronic myeloid leukaemia (n=62) aged >12 years were recruited from January 2020 to January 2021. Patients with progressive disease, pregnancy and hypercalcaemia were excluded.

Intervention

Oral vitamin D

SUBMITTER: Bandyopadhyay A 

PROVIDER: S-EPMC10465917 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature