Evaluating synthetic computed tomography images for adaptive radiotherapy decision making in head and neck cancer.

ABSTRACT:

Background and purpose

Adaptive radiotherapy (ART) decision-making benefits from dosimetric information to supplement image inspection when assessing the significance of anatomical changes. This study evaluated a dosimetry-based clinical decision workflow for ART utilizing deformable registration of the original planning computed tomography (CT) image to the daily Cone Beam CT (CBCT) to replace the need for a replan CT for dose estimation.

Materials and methods

We used 12 retrospective Head & Neck patient cases having a ground truth - a replan CT (rCT) in response to anatomical changes apparent in the daily CBCT - to evaluate the accuracy of dosimetric assessment conducted on synthetic CTs (sCT) generated by deforming the original planning CT Hounsfield Units to the daily CB

SUBMITTER: Allen C 

PROVIDER: S-EPMC10465931 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature