An androgen receptor regulated gene score is associated with epithelial to mesenchymal transition features in triple negative breast cancers.

ABSTRACT:

Background

Androgen receptor (AR) is considered a marker of better prognosis in hormone receptor positive breast cancers (BC), however, its role in triple negative breast cancer (TNBC) is controversial. This may be attributed to intrinsic molecular differences or scoring methods for AR positivity. We derived AR regulated gene score and examined its utility in BC subtypes.

Methods

AR regulated genes were derived by applying a bioinformatic pipeline on publicly available microarray data sets of AR+ BC cell lines and gene score was calculated as average expression of six AR regulated genes. Tumors were divided into AR high and low based on gene score and associations with clinical parameters, circulating androgens, survival and epithelial to mesenchymal transition (EMT) markers

SUBMITTER: Rajarajan S 

PROVIDER: S-EPMC10465938 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature