A new class of potent liver injury protective compounds: Structural elucidation, total synthesis and bioactivity study.

ABSTRACT: A new class of potent liver injury protective compounds, phychetins A-D (1-4) featuring an unique 6/6/5/6/5 pentacyclic framework, were isolated and structurally characterized from a Chinese medicinal plant Phyllanthus franchetianus. Compounds 2-4 are three pairs of enantiomers that were initially obtained in a racemic manner, and were further separated by chiral HPLC preparation. Compounds 1-4 were proposed to be originated biosynthetically from a coexisting lignan via an intramolecular Friedel-Crafts reaction as the key step. A bioinspired total synthesis strategy was thus designated, and allowed the effective syntheses of compounds 2-4 in high yields. Some of compounds exhibited significant anti-inflammatory activitie

SUBMITTER: Ji K 

PROVIDER: S-EPMC10465957 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature