Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes.

ABSTRACT:

Objective

Depression is a common comorbidity of type 2 diabetes. We assessed the causal relationships and shared genetics between them.

Research design and methods

We applied two-sample, bidirectional Mendelian randomization (MR) to assess causality between type 2 diabetes and depression. We investigated potential mediation using two-step MR. To identify shared genetics, we performed 1) genome-wide association studies (GWAS) separately and 2) multiphenotype GWAS (MP-GWAS) of type 2 diabetes (19,344 case subjects, 463,641 control subjects) and depression using major depressive disorder (MDD) (5,262 case subjects, 86,275 control subjects) and self-reported depressive symptoms (n = 153,079) in the UK Biobank. We analyzed expression quantitative trait locus (eQTL) data from publ

SUBMITTER: Maina JG 

PROVIDER: S-EPMC10465984 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature