Association between per- and polyfluoroalkyl substances and risk of hypertension: a systematic review and meta-analysis.

ABSTRACT:

Background

Existing evidence indicates that exposure to per- and polyfluoroalkyl substances (PFASs) may increase the risk of hypertension, but the findings are inconsistent. Therefore, we aimed to explore the relationship between PFASs and hypertension through this systematic review and meta-analysis.

Methods

We searched PubMed, Embase, and the Web of Science databases for articles published in English that examined the relationship between PFASs and hypertension before 13 August 2022. The random effects model was used to aggregate the evaluation using Stata 15.0 for Windows. We also conducted subgroup analyses by region and hypertension definition. In addition, a sensitivity analysis was carried out to determine the robustness of the findings.

Results

The meta-analys

SUBMITTER: Xiao F 

PROVIDER: S-EPMC10466234 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature