Dataset Information

Healthcare use and clinical investigations before a diagnosis of ovarian cancer: a register-based study in Denmark.

ABSTRACT:

Background

Ovarian cancer (OC) is associated with a poor prognosis, which calls for earlier diagnosis. This study aimed to analyse the health care use in primary care and at hospitals among women with OC compared to non-cancerous women to identify a window of opportunity for earlier diagnosis.

Methods

This nationwide register-based observational cohort study included all Danish women aged ≥ 40 years who were diagnosed with a first-time OC or borderline ovarian tumour in 2012-2018 and with no previous cancer diagnosis (n = 4,255). For each case, ten non-cancerous women were identified (n = 42,550). We estimated monthly incidence rate ratios using a negative binomial regression model to assess the use of health care services. We calculated risk ratios of having multiple contacts to general practice before a diagnosis using a binary regression model.

Results

Cases had statistically significantly higher contact rates to general practice from five months prior to the diagnosis compared to references. From six to eight months prior to diagnosis, an increased use of transvaginal ultrasound and gynaecologist was seen for cases compared to references.

Conclusions

Increased healthcare use was seen relatively closely to the time of diagnosis for women with OC. This indicates a narrow window of opportunity for a timelier diagnosis. Still, the use of specialised assessment increased at six to eight months before the diagnosis. When women present unspecific symptoms, awareness of potential ovarian malignancies and safety-netting by the general practitioner may be pivotal.

Trial registration

Not relevant.

SUBMITTER: Rousing IG

PROVIDER: S-EPMC10466681 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Publications

Healthcare use and clinical investigations before a diagnosis of ovarian cancer: a register-based study in Denmark.

Rousing Isabella Gringer IG Vedsted Peter P Hjertholm Peter P Kallestrup Per P Baun Marie-Louise Ladegaard ML Virgilsen Line Flytkjaer LF

BMC primary care 20230830 1

<h4>Background</h4>Ovarian cancer (OC) is associated with a poor prognosis, which calls for earlier diagnosis. This study aimed to analyse the health care use in primary care and at hospitals among women with OC compared to non-cancerous women to identify a window of opportunity for earlier diagnosis.<h4>Methods</h4>This nationwide register-based observational cohort study included all Danish women aged ≥ 40 years who were diagnosed with a first-time OC or borderline ovarian tumour in 2012-2018 ...[more]

PMID: 37644395

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Dataset Information

Healthcare use and clinical investigations before a diagnosis of ovarian cancer: a register-based study in Denmark.

Background

Methods

Results

Conclusions

Trial registration

Publications

Healthcare use and clinical investigations before a diagnosis of ovarian cancer: a register-based study in Denmark.

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