Complete-genome sequencing and comparative genomic characterization of bla_NDM-5 carrying Citrobacter freundii isolates from a patient with multiple infections.

ABSTRACT:

Background

The emergence and wide spread of carbapenemase-producing Enterobacteriaceae (CPE) poses a growing threat to global public health. However, clinically derived carbapenemase-producing Citrobacter causing multiple infections has rarely been investigated. Here we first report the isolation and comparative genomics of two bla_NDM-5 carrying Citrobacter freundii (C. freundii) isolates from a patient with bloodstream and urinary tract infections.

Results

Antimicrobial susceptibility testing showed that both bla_NDM-5 carrying C. freundii isolates were multidrug-resistant. Positive modified carbapenem inactivation method (mCIM) and EDTA-carbapenem inactivation method (eCIM) results suggested metallo-carbapenemase production. PCR and sequencing confirme

SUBMITTER: Ye J 

PROVIDER: S-EPMC10466682 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature