Cutaneous allodynia as predictor for treatment response in chronic migraine: a cohort study.

ABSTRACT:

Background

Central sensitisation is an important mechanism in migraine chronification. It is presumed to occur in second and third order neurons sequentially, resulting in an analogous spatial distribution of cutaneous allodynia with cephalic and extracephalic symptoms. We investigated whether allodynia, and its subtypes based on spatial distribution and type of stimulus, predict response to treatment in chronic migraine patients.

Methods

This study was conducted as part of the CHARM study (NTR3440), a randomized, double-blind, placebo-controlled trial in chronic migraine patients with medication overuse. We included 173 patients. The presence of cutaneous allodynia at baseline was established with the Allodynia Symptom Checklist. Primary endpoint was reversion from chronic

SUBMITTER: Pijpers JA 

PROVIDER: S-EPMC10466691 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature