MUC16 stimulates neutrophils to an inflammatory and immunosuppressive phenotype in ovarian cancer.

ABSTRACT:

Background

MUC16 (CA125) is a commonly used tumor marker for ovarian cancer screening and reported to be an immunosuppressive factor by acting on the sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) on the surface of natural killer cells (NK cells), B cells, and monocytes. However, the role of MUC16 on neutrophils in the tumor microenvironment remains to be further explored.

Methods

The correlation between the proportion and count of peripheral blood cells, serum inflammatory-related factors and serum MUC16 (CA125) level in patients was constructed based on clinical samples. RNAseq data was obtained from TCGA and sequencing of ovarian cancer tissues, followed by TIMER immune cell infiltration and correlation analysis. Ovarian cancer organoid was constructed to sti

SUBMITTER: Wu Y 

PROVIDER: S-EPMC10466733 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature