Tumor-associated macrophages in nanomaterial-based anti-tumor therapy: as target spots or delivery platforms.

ABSTRACT: Targeting tumor-associated macrophages (TAMs) has emerged as a promising approach in cancer therapy. This article provides a comprehensive review of recent advancements in the field of nanomedicines targeting TAMs. According to the crucial role of TAMs in tumor progression, strategies to inhibit macrophage recruitment, suppress TAM survival, and transform TAM phenotypes are discussed as potential therapeutic avenues. To enhance the targeting capacity of nanomedicines, various approaches such as the use of ligands, immunoglobulins, and short peptides are explored. The utilization of live programmed macrophages, macrophage cell membrane-coated nanoparticles and macrophage-derived extracellular vesicles as drug delivery platforms is also highlighted, offering improved biocompatibility and pro

SUBMITTER: Zheng J 

PROVIDER: S-EPMC10466823 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature