ApoE gene polymorphisms and metals and their interactions with cognitive function.

ABSTRACT:

Objective

To analyze the relationship between plasma metal elements, ApoE gene polymorphisms and the interaction between the two and impaired cognitive function in elderly population.

Method

A stratified sample was drawn according to the age of the study population, and 911 subjects were included. Baseline information and health indicators were obtained, and cognitive function status was assessed by health examination, a general questionnaire and Mini-Mental Status Examination. Plasma metal elements were measured, and SNP typing was performed. Binary logistic regression was used to analyze the factors influencing cognitive function status and the association between the SNP genetic pattern of the ApoE gene and cognitive function.

Results

The differences in gene freque

SUBMITTER: Ye Z 

PROVIDER: S-EPMC10466837 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature