Cerebrospinal fluid camk2a levels at baseline predict long-term progression in multiple sclerosis.

ABSTRACT:

Background

Multiple sclerosis (MS) remains a highly unpredictable disease. Many hope that fluid biomarkers may contribute to better stratification of disease, aiding the personalisation of treatment decisions, ultimately improving patient outcomes.

Objective

The objective of this study was to evaluate the predictive value of CSF brain-specific proteins from early in the disease course of MS on long term clinical outcomes.

Methods

In this study, 34 MS patients had their CSF collected and stored within 5 years of disease onset and were then followed clinically for at least 15 years. CSF concentrations of 64 brain-specific proteins were analyzed in the 34 patient CSF, as well as 19 age and sex-matched controls, using a targeted liquid-chromatography tandem mass spectrome

SUBMITTER: Sohaei D 

PROVIDER: S-EPMC10466840 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature