Designs used in published therapeutic studies of rare superficial vascular anomalies: a systematic literature search.

ABSTRACT:

Background

Rare superficial vascular anomalies represent a wide range of diseases. Their management is difficult given the broad spectrum and the lack of clinical trials assessing treatment efficacy. A randomized clinical trial of vascular anomalies is difficult because of the rarity of the diseases and is enhanced by the population of interest often being children. Therefore, suitable designs are needed. We conducted a methodological systematic literature search to identify designs implemented for investigating the treatment of rare superficial vascular anomalies.

Methods

We conducted a literature search on January 25, 2021, of the PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, ClinicalTrials.gov and European Union Clinical Trials Register databas

SUBMITTER: Allemang-Trivalle A 

PROVIDER: S-EPMC10466846 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature