An insight into the potential role of LINC00968 in luminal breast cancer: Case-control study and bioinformatics analysis.

ABSTRACT:

Background

Luminal A and B subtypes of breast cancer (BC) comprises up to 70% of all BC patients. LncRNAs can affect many biological and pathological processes, and dysregulation of them is related to human cancers. The potential role of lncRNA LINC00968 in luminal BC is still unclear.

Materials and methods

We analyzed the LINC00968 expression across 44 paired luminal BC tissues from the TCGA-BRCA RNA sequencing dataset. Besides, we used the GEPIA2 web server and GENEVESTIGATOR software, as well. Real-Time Quantitative Reverse Transcription PCR (qRT-PCR) assay was performed to confirm the LINC00968 expression in 71 paired luminal BC tissues and two luminal A cell lines (MCF7 and T47D). Moreover, to better understanding the potential role of LINC00968 in luminal BC, computati

SUBMITTER: Arabpour M 

PROVIDER: S-EPMC10466910 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature