Alzheimer's Disease Protein Relevance Analysis Using Human and Mouse Model Proteomics Data.

ABSTRACT: The principles governing genotype-phenotype relationships are still emerging(1-3), and detailed translational as well as transcriptomic information is required to understand complex phenotypes, such as the pathogenesis of Alzheimer's disease. For this reason, the proteomics of Alzheimer disease (AD) continues to be studied extensively. Although comparisons between data obtained from humans and mouse models have been reported, approaches that specifically address the between-species statistical comparisons are understudied. Our study investigated the performance of two statistical methods for identification of proteins and biological pathways associated with Alzheimer's disease for cross-species comparisons, taking specific data analysis challenges into account, including collinearity, dime

SUBMITTER: Shi C 

PROVIDER: S-EPMC10467016 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature