Human amygdala involvement in Alzheimer's disease revealed by stereological and dia-PASEF analysis.

ABSTRACT: Alzheimer's disease (AD) is characterized by the accumulation of pathological amyloid-β (Aβ) and Tau proteins. According to the prion-like hypothesis, both proteins can seed and disseminate through brain regions through neural connections and glial cells. The amygdaloid complex (AC) is involved early in the disease, and its widespread connections with other brain regions indicate that it is a hub for propagating pathology. To characterize changes in the AC as well as the involvement of neuronal and glial cells in AD, a combined stereological and proteomic analysis was performed in non-Alzheimer's disease and AD human samples. The synaptic alterations identified by proteomic data analysis could be related to the volume reduction observed in AD by the Cavalieri probe without neuronal loss. T

SUBMITTER: Gonzalez-Rodriguez M 

PROVIDER: S-EPMC10467039 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature