Intravaginal Combination Therapy of Acetic and Lactic Acid in premenopausal women with recurrent vulvovaginal candidiasis: A randomized, double-blind placebo-controlled feasibility trial.

ABSTRACT:

Background

Recurrent vulvovaginal candidiasis management primarily entails azole therapy used as required or as an extended daily or weekly maintenance therapy for 6 months or more. Unfortunately, relapse within 3-6 months of ceasing maintenance therapy is experienced for more than half the patients, for whom indefinite treatment is required.

Objectives

To explore the feasibility of trial design examining a prophylaxis treatment to prevent recurrent vulvovaginal candidiasis symptomatic episodes and reduce adverse effects.

Study design

A double-blinded randomized controlled feasibility trial was conducted in Australia. Women with recurrent vulvovaginal candidiasis were enrolled.

Methods

An intravaginal prophylaxis application of lactic acid and acetic acid (Intr

SUBMITTER: Strydom MB 

PROVIDER: S-EPMC10467244 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature