Genome instability-derived genes as a novel prognostic signature for lung adenocarcinoma.

ABSTRACT: Background: An increasing number of patients are being diagnosed with lung adenocarcinoma, but there remains limited progress in enhancing prognostic outcomes and improving survival rates for these patients. Genome instability is considered a contributing factor, as it enables other hallmarks of cancer to acquire functional capabilities, thus allowing cancer cells to survive, proliferate, and disseminate. Despite the importance of genome instability in cancer development, few studies have explored the prognostic signature associated with genome instability for lung adenocarcinoma. Methods: In the study, we randomly divided 397 lung adenocarcinoma patients from The Cancer Genome Atlas database into a training group (n = 199) and a testing group (n = 198). By calc

SUBMITTER: Zhang X 

PROVIDER: S-EPMC10467266 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature