Antiproliferative effect of boldine on neural progenitor cells and on glioblastoma cells.

ABSTRACT:

Introduction

The subventricular zone (SVZ) is a brain region that contains neural stem cells and progenitor cells (NSCs/NPCs) from which new neurons and glial cells are formed during adulthood in mammals. Recent data indicate that SVZ NSCs are the cell type that acquires the initial tumorigenic mutation in glioblastoma (GBM), the most aggressive form of malignant glioma. NSCs/NPCs of the SVZ present hemichannel activity whose function has not yet been fully elucidated. In this work, we aimed to analyze whether hemichannel-mediated communication affects proliferation of SVZ NPCs and GBM cells.

Methods and results

For that purpose, we used boldine, an alkaloid derived from the boldo tree (Peumus boldus), that inhibits connexin and pannexin hemichannels, but without affe

SUBMITTER: Jimenez-Madrona E 

PROVIDER: S-EPMC10467274 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature