Prediabetes, intervening diabetes and subsequent risk of dementia: the Atherosclerosis Risk in Communities (ARIC) study.

ABSTRACT:

Aims/hypothesis

The aim of this work was to evaluate whether the association of prediabetes with dementia is explained by the intervening onset of diabetes.

Methods

Among participants of the Atherosclerosis Risk in Communities (ARIC) study we defined baseline prediabetes as HbA_1c 39-46 mmol/mol (5.7-6.4%) and subsequent incident diabetes as a self-reported physician diagnosis or use of diabetes medication. Incident dementia was ascertained via active surveillance and adjudicated. We quantified the association of prediabetes with dementia risk before and after accounting for the subsequent development of diabetes among ARIC participants without diabetes at baseline (1990-1992; participants aged 46-70 years). We also evaluated whether age at diabetes diagnosis modif

SUBMITTER: Hu J 

PROVIDER: S-EPMC10467356 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature