Glucose exchange parameters in a subset of physiological conditions.

ABSTRACT: The chemical exchange of labile protons of the hydroxyl groups can be exploited in a variety of magnetic resonance experiments to gain information about the groups and their physicochemical environment. The exchangeable -OH protons provide important contributions to the T₂ of water signals thus contributing to the T₂-weighted contrast of MRI images. This exchange can be exploited more specifically and sensitively in chemical exchange saturation transfer (CEST) or longitudinal rotating frame relaxation (T_1,ρ) experiments. Since glucose is omnipresent in living organisms, it may be seen as a rather universal probe. Even though the potential was first recognized many years ago, practical use has remained scarce due to numerous challenges.

SUBMITTER: Mares J 

PROVIDER: S-EPMC10467565 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature