Dynamic cancer drivers: a causal approach for cancer driver discovery based on bio-pathological trajectories.

ABSTRACT: The traditional way for discovering genes which drive cancer (namely cancer drivers) neglects the dynamic information of cancer development, even though it is well known that cancer progresses dynamically. To enhance cancer driver discovery, we expand cancer driver concept to dynamic cancer driver as a gene driving one or more bio-pathological transitions during cancer progression. Our method refers to the fact that cancer should not be considered as a single process but a compendium of altered biological processes causing the disease to develop over time. Reciprocally, different drivers of cancer can potentially be discovered by analysing different bio-pathological pathways. We propose a novel approach for causal inference of genes driving one or more core processes during cancer developm

SUBMITTER: Cifuentes-Bernal AM 

PROVIDER: S-EPMC10467634 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature