Reconciliation and evolution of Penicillium rubens genome-scale metabolic networks-What about specialised metabolism?

ABSTRACT: In recent years, genome sequencing of filamentous fungi has revealed a high proportion of specialised metabolites with growing pharmaceutical interest. However, detecting such metabolites through in silico genome analysis does not necessarily guarantee their expression under laboratory conditions. However, one plausible strategy for enabling their production lies in modifying the growth conditions. Devising a comprehensive experimental design testing in different culture environments is time-consuming and expensive. Therefore, using in silico modelling as a preliminary step, such as Genome-Scale Metabolic Network (GSMN), represents a promising approach to predicting and understanding the observed specialised metabolite production in a given organism. To address these questions, we reconstr

SUBMITTER: Negre D 

PROVIDER: S-EPMC10468094 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature