Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor.

ABSTRACT: Signal perception is a key function in regulating biological activities and adapting to changing environments. Per-Arnt-Sim (PAS) domains are ubiquitous sensors found in diverse receptors in bacteria, archaea, and eukaryotes, but their origins, distribution across the tree of life, and extent of their functional diversity are not fully characterized. Here, we show that using sequence conservation and structural information, it is possible to propose specific and potential functions for a large portion of nearly 3 million PAS domains. Our analysis suggests that PAS domains originated in bacteria and were horizontally transferred to archaea and eukaryotes. We reveal that gas sensing via a heme cofactor evolved independently in several lineages, whereas redox and light sensing via flavin aden

SUBMITTER: Xing J 

PROVIDER: S-EPMC10468136 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature