Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures.

ABSTRACT: Large-effect loci-those statistically significant loci discovered by genome-wide association studies or linkage mapping-associated with key traits segregate amidst a background of minor, often undetectable, genetic effects in wild and domesticated plants and animals. Accurately attributing mean differences and variance explained to the correct components in the linear mixed model analysis is vital for selecting superior progeny and parents in plant and animal breeding, gene therapy, and medical genetics in humans. Marker-assisted prediction and its successor, genomic prediction, have many advantages for selecting superior individuals and understanding disease risk. However, these two approaches are less often integrated to study complex traits with different genetic architectures. This sim

SUBMITTER: Feldmann MJ 

PROVIDER: S-EPMC10468314 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature