Population-based heteropolymer design to mimic protein mixtures.

ABSTRACT: Biological fluids, the most complex blends, have compositions that constantly vary and cannot be molecularly defined¹. Despite these uncertainties, proteins fluctuate, fold, function and evolve as programmed^2-4. We propose that in addition to the known monomeric sequence requirements, protein sequences encode multi-pair interactions at the segmental level to navigate random encounters^5,6; synthetic heteropolymers capable of emulating such interactions can replicate how proteins behave in biological fluids individually and collectively. Here, we extracted the chemical characteristics and sequential arrangement along a protein chain at the segmental level from natural protein libraries and used the information to design heteropolymer ensembles as mixtures of

SUBMITTER: Ruan Z 

PROVIDER: S-EPMC10468399 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature