Impaired resolution of blood transcriptomes through tuberculosis treatment with diabetes comorbidity.

ABSTRACT:

Background

People with diabetes are more likely to develop tuberculosis (TB) and to have poor TB-treatment outcomes than those without. We previously showed that blood transcriptomes in people with TB-diabetes (TB-DM) co-morbidity have excessive inflammatory and reduced interferon responses at diagnosis. It is unknown whether this persists through treatment and contributes to the adverse outcomes.

Methods

Pulmonary TB patients recruited in South Africa, Indonesia and Romania were classified as having TB-DM, TB with prediabetes, TB-related hyperglycaemia or TB-only, based on glycated haemoglobin concentration at TB diagnosis and after 6 months of TB treatment. Gene expression in blood at diagnosis and intervals throughout treatment was measured by unbiased RNA-Seq and targete

SUBMITTER: Eckold C 

PROVIDER: S-EPMC10468587 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature