NLRP3 is essential for neutrophil polarization and chemotaxis in response to leukotriene B4 gradient.

ABSTRACT: Neutrophil recruitment to sites of infection and inflammation is an essential process in the early innate immune response. Upon activation, a subset of neutrophils rapidly assembles the multiprotein complex known as the NLRP3 inflammasome. The NLRP3 inflammasome forms at the microtubule organizing center, which promotes the formation of interleukin (IL)-1β and IL-18, essential cytokines in the immune response. We recently showed that mice deficient in NLRP3 (NLRP3^-/-) have reduced neutrophil recruitment to the peritoneum in a model of thioglycolate-induced peritonitis. Here, we tested the hypothesis that this diminished recruitment could be, in part, the result of defects in neutrophil chemotaxis. We find that NLRP3^-/- neutrophils show loss of cell polarization, as we

SUBMITTER: Van Bruggen S 

PROVIDER: S-EPMC10468616 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature