Inferring the distributions of fitness effects and proportions of strongly deleterious mutations.

ABSTRACT: The distribution of fitness effects is a key property in evolutionary genetics as it has implications for several evolutionary phenomena including the evolution of sex and mating systems, the rate of adaptive evolution, and the prevalence of deleterious mutations. Despite the distribution of fitness effects being extensively studied, the effects of strongly deleterious mutations are difficult to infer since such mutations are unlikely to be present in a sample of haplotypes, so genetic data may contain very little information about them. Recent work has attempted to correct for this issue by expanding the classic gamma-distributed model to explicitly account for strongly deleterious mutations. Here, we use simulations to investigate one such method, adding a parameter (plth) to capture the

SUBMITTER: Charmouh AP 

PROVIDER: S-EPMC10468728 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature