CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is one of the most prevalent and debilitating joint diseases worldwide. RA is characterized by synovial inflammation (synovitis), which is linked to the development of joint destruction. Magnetic resonance imaging and ultrasonography are widely being used to detect the presence and extent of synovitis. However, these techniques do not reveal the activation status of inflammatory cells such as macrophages that play a crucial role in synovitis and express CD64 (Fc gamma receptor (FcγR)I) which is considered as macrophage activation marker.

Objectives

We aimed to investigate CD64 expression and its correlation with pro-inflammatory cytokines and pro-damaging factors in human-derived RA synovium. Furthermore, we aimed to set up a molecular im

SUBMITTER: Theeuwes WF 

PROVIDER: S-EPMC10468866 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature