Hepatocyte-specific Sox9 knockout ameliorates acute liver injury by suppressing SHP signaling and improving mitochondrial function.

ABSTRACT:

Background and aims

Sex determining region Y related high-mobility group box protein 9 (Sox9) is expressed in a subset of hepatocytes, and it is important for chronic liver injury. However, the roles of Sox9⁺ hepatocytes in response to the acute liver injury and repair are poorly understood.

Methods

In this study, we developed the mature hepatocyte-specific Sox9 knockout mouse line and applied three acute liver injury models including PHx, CCl₄ and hepatic ischemia reperfusion (IR). Huh-7 cells were subjected to treatment with hydrogen peroxide (H₂O₂) in order to induce cellular damage in an in vitro setting.

Results

We found the positive effect of Sox9 deletion on acute liver injury repair. Small heterodimer partner (SHP) e

SUBMITTER: Qin D 

PROVIDER: S-EPMC10468867 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature