Differentiation of silent corticotroph pituitary neuroendocrine tumors (PitNETs) from non-functioning PitNETs using kinetic analysis of dynamic MRI.

ABSTRACT:

Purpose

Silent corticotroph pituitary adenomas (SCAs)/pituitary neuroendocrine tumors (PitNETs) are common non-functioning pituitary adenomas (NFAs)/PitNETs with a clinically aggressive course. This study aimed to investigate the ability of time-intensity analysis of dynamic magnetic resonance imaging (MRI) for distinguishing adrenocorticotropic hormone (ACTH)-positive SCAs and ACTH-negative SCAs from other NFAs.

Materials and methods

We retrospectively evaluated the dynamic MRI findings of patients with NFAs. The initial slope of the kinetic curve (slope_ini) obtained by dynamic MRI for each tumor was analyzed using a modified empirical mathematical model. The maximum slope of the kinetic curve (slope_max) was obtained by geometric calculation.

Result

SUBMITTER: Amano T 

PROVIDER: S-EPMC10468932 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature