A novel inclusion complex of oxybenzone with C-methylresorcin[4]arene deters skin permeation† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ra01890c

ABSTRACT: Oxybenzone (OXB), a very widely used sunscreen ingredient has the potential to block both UVA and UVB but can penetrate through skin. Studies have revealed its presence in the blood and urine of most humans, which may lead to long-term health effects. As the confined cavities of macrocycles can alter the physical and chemical properties of encapsulated guests, in this study, we investigated the formation of host–guest complexes between C-methylresorcin[4]arene and OXB. Combined experimental (NMR spectroscopy, UV/vis absorption, and fluorescence spectroscopy) and theoretical investigation confirmed the formation of a weak host–guest complex that had a 1 : 1 stoichiometry. Furthermore, skin permeation testing revealed that complexation by C-methylresorcin[4]arene significantly reduced the sk

SUBMITTER: Kang X 

PROVIDER: S-EPMC10468953 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature