Systematic Mendelian randomization study of the effect of gut microbiome and plasma metabolome on severe COVID-19.

ABSTRACT:

Background

COVID-19 could develop severe respiratory symptoms in certain infected patients, especially in the patients with immune disorders. Gut microbiome and plasma metabolome act important immunological modulators in the human body and could contribute to the immune responses impacting the progression of COVID-19. However, the causal relationship between specific intestinal bacteria, metabolites and severe COVID-19 remains not clear.

Methods

Based on two-sample Mendelian randomization (MR) framework, the causal effects of 131 intestinal taxa and 452 plasma metabolites on severe COVID-19 were evaluated. Single nucleotide polymorphisms (SNPs) strongly associated with the abundance of intestinal taxa and the concentration of plasma metabolites had been utilized as the instr

SUBMITTER: Yan H 

PROVIDER: S-EPMC10468967 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature